The FAM89B Polyclonal Antibody (PAC016307) is a valuable tool for research on FAM89B, a protein involved in various cellular processes, including gene regulation and cell signaling. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blotting and immunohistochemistry applications.FAM89B is a potential regulator of cellular function, with emerging evidence suggesting its involvement in cancer progression and other diseases.
By targeting FAM89B with this antibody, researchers can study its role in cell biology and disease pathology, aiding in the development of novel therapeutic strategies.With its high reactivity and specificity, the FAM89B Polyclonal Antibody (PAC016307) is a reliable tool for investigating the function and expression of FAM89B in various biological systems, making it a valuable asset for studies in molecular biology, cancer research, and beyond.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16307(FAM89B Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: PACO16307(FAM89B Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16307(FAM89B Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Mtvr1 (mammary tumor virus receptor homolog 1), also known as FAM89B (family with sequence similarity 89, member B), is a 176 amino acid, protein that exists as two alternatively spliced isoforms. Belonging to the FAM89 family, Mtvr1 is encoded by a gene that maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.
Synonyms:
family with sequence similarity 89, member B
UniProt Protein Function:
FAM89B: Belongs to the FAM89 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, misc.Chromosomal Location of Human Ortholog: 11q13Cellular Component: cell surface; cytoplasmBiological Process: negative regulation of transforming growth factor beta receptor signaling pathway
