Description
FANCA Antibody (CAB7671)
The FANCA Antibody (CAB7671) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, is highly specific for human FANCA and has been validated for use in various applications, including Western blotting.FANCA is a key member of the Fanconi Anemia pathway, which is involved in DNA repair and the maintenance of genomic stability. Dysregulation of this pathway can lead to the development of Fanconi Anemia and an increased susceptibility to cancer.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
| Product Name: | FANCA Antibody |
| SKU: | CAB7671 |
| Size: | 20μL, 100μL |
| Reactivity: | Human |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||
| Sequence: | MSDS WVPN SASG QDPG GRRR AWAE LLAG RVKR EKYN PERA QKLK ESAV RLLR SHQD LNAL LLEV EGPL CKKL SLSK VIDC DSSE AYAN HSSS FIGS ALQD QASR LGVP VGIL SAGM VASS VGQI CTAP AETS HPVL LTVE QRKK LSSL LEFA QYLL AHSM FSRL SFCQ ELWK IQSS LLLE AVWH LHVQ GIVS LQEL LESH PDMH AVGS WLFR NLCC LCEQ MEAS CQHA DVAR AMLS DFVQ MFVL RGFQ KNSD LRRT VEPE KMPQ VTVD VLQR MLI | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | FA, FA1, FAA, FAH, FA-H, FACA, FANCH, FANCA |
| Positive Sample: | HeLa |
| Cellular Localization: | Cytoplasm, Nucleus. |
| Calculated MW: | 163kDa |
| Observed MW: | 163kDa |
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.
| Purification Method | Affinity purification |
| Gene ID | 2175 |
| RRID | AB_2769414 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of lysates from HeLa cells, using FANCA Rabbit pAb (CAB7671) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s. |
