Description
FANCI Antibody (CAB3447)
The FANCI Antibody (CAB3447) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is produced in rabbits and specifically targets human samples, making it a reliable choice for Western blot applications. By binding to the FANCI protein, this antibody allows for the detection and analysis of FANCI expression in a variety of cell types, making it an invaluable asset for studies in molecular biology and cancer research.FANCI is a key component of the Fanconi Anemia (FA) pathway, a DNA repair pathway that safeguards against DNA damage and genomic instability.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
| Product Name: | FANCI Antibody |
| SKU: | CAB3447 |
| Size: | 20μL, 100μL |
| Reactivity: | Human |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||
| Sequence: | DQDV EVEK TNHF AIVN LRTA APTV CLLV LSQA EKVL EEVD WLIT KLKG QVSQ ETLS EEAS SQAT LPNQ PVEK AIIM QLGT LLTF FHEL VQTA LPSG SCVD TLLK DLCK MYTT LTAL VRYY LQVC QSSG GIPK NMEK LVKL SGSH LTPL CYSF ISYV QNKS KSLN YTGE KKEK PAAV ATAM ARVL RETK PIPN LIFA IEQY EKFL IHLS KKSK VNLM QHMK LSTS RDFK IKGN ILDM VLRE DGED ENEE GTAS EHGG QNKE PAKK KRKK | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | KIAA1794, FANCI |
| Positive Sample: | HeLa, 293T, MCF7 |
| Cellular Localization: | Nucleus. |
| Calculated MW: | 149kDa |
| Observed MW: | 149kDa |
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.
| Purification Method | Affinity purification |
| Gene ID | 55215 |
| RRID | AB_2765116 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of various lysates using FANCI Rabbit pAb (CAB3447) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s. |
