Description
FANCM Rabbit Polyclonal Antibody (CAB7602)
The FANCM Polyclonal Antibody (CAB7602) is a valuable tool for researchers studying the FANCM protein, a key player in DNA repair and genome stability. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the FANCM protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for research in fields such as molecular biology and cancer biology.
FANCM, a member of the Fanconi anemia complementation group, is essential for maintaining genomic integrity and preventing DNA damage. Mutations in the FANCM gene have been linked to a variety of diseases, including cancer and Fanconi anemia. By studying the function of FANCM using this antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
| Product Name: | FANCM Rabbit Polyclonal Antibody |
| SKU: | CAB7602 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 390-660 of human FANCM (NP_065988.1). |
| Sequence: | MDGT KGMT RSKN ELGR NEDF MKLY NHLE CMFA RTRS TSAN GISA IQQG DKNK KFVY SHPK LKKL EEVV IEHF KSWN AENT TEKK RDET RVMI FSSF RDSV QEIA EMLS QHQP IIRV MTFV GHAS GKST KGFT QKEQ LEVV KQFR DGGY NTLV STCV GEEG LDIG EVDL IICF DSQK SPIR LVQR MGRT GRKR QGRI VIIL SEGR EERI YNQS QSNK RSIY KAIS SNRQ VLHF YQRS PRMV PDGI NPKL HKMF ITHG VYEP EKPS RNLQ RKS |
| Tested Applications: | WB IF/ICC ELISA |
| Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
| Synonyms: | POF15; SPGF28; FAAP250; KIAA1596; FANCM |
| Conjugate: | Unconjugated |
| Cellular Localization: | Nucleus. |
| Calculated MW: | 232kDa |
| Observed MW: | Refer to figures |
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants.
| Purification Method: | Affinity purification |
| Gene ID: | 57697 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
 | Immunofluorescence analysis of A549 cells using FANCM antibody (CAB7602). |
