The FARP2 Polyclonal Antibody (PAC021707) is a valuable tool for researchers studying FARP2, a protein involved in neuronal development and synaptic function. This antibody, derived from rabbits, is highly specific to human samples and is validated for use in Western blot and immunofluorescence applications. By targeting the FARP2 protein, this antibody allows for the detection and analysis of FARP2 expression in various cell types, making it ideal for studies in neuroscience and neurobiology.FARP2, also known as FERM, RhoGEF, and pleckstrin domain-containing protein 2, plays a crucial role in neuronal development, dendritic spine formation, and synaptic plasticity.
Dysregulation of FARP2 has been implicated in neurological disorders such as autism, schizophrenia, and intellectual disabilities. Therefore, exploring the function of FARP2 using this antibody may provide valuable insights into the pathophysiology of these conditions and lead to the development of potential therapeutic strategies.
Antibody Name:
FARP2 Antibody (PACO21707)
Antibody SKU:
PACO21707
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from Internal of human FIR.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HuvEc cells, using FIR antibody.
Background:
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion By similarity. The MGC Project Team, Genome Res. 14:2121-2127(2004).
Synonyms:
FERM; RhoGEF and pleckstrin domain protein 2; FGD1-related Cdc42-GEF; FIR; FRG
UniProt Protein Function:
FARP2: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Cell development/differentiation; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Biological Process: actin cytoskeleton reorganization; cell adhesion; hair cycle process; neuron remodeling; osteoclast differentiation; positive regulation of GTPase activity; Rac protein signal transduction; regulation of integrin activation; regulation of Rho protein signal transduction
FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform b
NCBI Synonym Full Names:
FERM, ARH/RhoGEF and pleckstrin domain protein 2
NCBI Official Symbol:
FARP2Â Â
NCBI Official Synonym Symbols:
FIR; FRG; PLEKHC3Â Â
NCBI Protein Information:
FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2
UniProt Protein Name:
FERM, ARHGEF and pleckstrin domain-containing protein 2
UniProt Synonym Protein Names:
FERM domain-including RhoGEF; FIR; FERM, RhoGEF and pleckstrin domain-containing protein 2; Pleckstrin homology domain-containing family C member 3; PH domain-containing family C member 3
