Description
FARP2 Antibody (PACO26685)
The FARP2 Polyclonal Antibody (PAC026685) is a valuable tool for research involving FARP2, a protein involved in neuronal development and synaptic plasticity. This antibody, produced in rabbits, has been shown to be highly specific for human samples and is validated for use in Western blot applications. By binding to the FARP2 protein, this antibody enables researchers to detect and analyze FARP2 expression in various cell types, making it an excellent choice for studies in neuroscience and neurodevelopmental disorders.FARP2, also known as FGD4, is a guanine nucleotide exchange factor that regulates the activity of Rho GTPases, key signaling molecules involved in neuronal growth and connectivity.
Dysregulation of FARP2 has been implicated in neurological disorders such as autism and schizophrenia, highlighting the importance of studying its function in normal and pathological conditions. By investigating the role of FARP2, researchers can gain insights into the molecular mechanisms underlying brain development and function, opening up new avenues for therapeutic interventions in neurodevelopmental disorders.
| Antibody Name: | FARP2 Antibody (PACO26685) |
| Antibody SKU: | PACO26685 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human FERM, ARHGEF and pleckstrin domain-containing protein 2 protein (261-550AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO26685 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO26685 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO26685 at dilution of 1:100. |
| Background: | Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). |
| Synonyms: | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3), FARP2, KIAA0793 PLEKHC3 |
| UniProt Protein Function: | FARP2: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytoplasm; cytoskeleton; cytosol Molecular Function:cytoskeletal protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity Biological Process: actin cytoskeleton reorganization; cell adhesion; hair cycle process; neuron remodeling; osteoclast differentiation; positive regulation of GTPase activity; Rac protein signal transduction; regulation of integrin activation; regulation of Rho protein signal transduction |
| UniProt Code: | O94887 |
| NCBI GenInfo Identifier: | 545478372 |
| NCBI Gene ID: | 9855 |
| NCBI Accession: | NP_001269912.1 |
| UniProt Secondary Accession: | O94887,Q53QM5, Q8WU27, Q9UFE7, B7Z6J8, F5GZ84, |
| UniProt Related Accession: | O94887 |
| Molecular Weight: | 119 kDa |
| NCBI Full Name: | FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform b |
| NCBI Synonym Full Names: | FERM, ARH/RhoGEF and pleckstrin domain protein 2 |
| NCBI Official Symbol: | FARP2Â Â |
| NCBI Official Synonym Symbols: | FIR; FRG; PLEKHC3Â Â |
| NCBI Protein Information: | FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2 |
| UniProt Protein Name: | FERM, ARHGEF and pleckstrin domain-containing protein 2 |
| UniProt Synonym Protein Names: | FERM domain-including RhoGEF; FIR; FERM, RhoGEF and pleckstrin domain-containing protein 2; Pleckstrin homology domain-containing family C member 3; PH domain-containing family C member 3 |
| UniProt Gene Name: | FARP2Â Â |
| Antibodies | ELISA Kits |
| FARP2 Antibody (PACO00805) | FIR Colorimetric Cell-Based ELISA |
| FARP2 Antibody (PACO09233) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
