The FAT3 Polyclonal Antibody (PACO19019) is a valuable tool for researchers studying FAT3, a cell surface protein implicated in cell adhesion and signaling pathways. This antibody, produced in rabbits, is highly specific for FAT3 in human samples and has been validated for use in Western blot applications. By binding to the FAT3 protein, this antibody allows for the detection and analysis of FAT3 expression in various cell types, making it ideal for studies in developmental biology and cancer research.
FAT3, also known as fetal Alzheimer antigen, plays a crucial role in cell migration, adhesion, and neuronal development. Its involvement in these processes makes it a promising target for research on neurodevelopmental disorders, cancer metastasis, and other diseases where cell movement and interaction are dysregulated. Investigating the function of FAT3 is essential for gaining insights into these pathological conditions and developing strategies for intervention and treatment.
Antibody Name:
FAT3 Antibody (PACO19019)
Antibody SKU:
PACO19019
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human FAT3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19019(FAT3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO19019(FAT3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). The atypical cadherin Fat3 ensures that retinal amacrine cells (ACs) develop this unipolar morphology. Fat3 expression was restricted to the nervous system, for example in the brain, it is expressed in a variety of regions and axon fascicles. However, its strongest expression was observed in the olfactory bulb and retina.
Synonyms:
FAT tumor suppressor homolog 3 (Drosophila)
UniProt Protein Function:
FAT3: May play a role in the interactions between neurites derived from specific subsets of neurons during development. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 11q14.3Cellular Component: integral to membrane; plasma membraneMolecular Function: calcium ion bindingBiological Process: multicellular organismal development; homophilic cell adhesion
