The FCN3 Polyclonal Antibody (CAB17352) is a valuable tool for researchers studying FCN3, a protein involved in immune response modulation and regulation. This antibody, produced in rabbits, shows high reactivity towards human samples and is validated for use in Western blot applications.FCN3, also known as ficolin-3, is a key player in the innate immune system, where it functions as a pattern recognition receptor, recognizing and binding to microbial pathogens. By detecting foreign invaders, FCN3 helps initiate the immune response, making it a crucial component in the defense against infections.
Researchers studying infectious diseases, autoimmune disorders, and inflammatory conditions can benefit from utilizing the FCN3 Polyclonal Antibody to detect and analyze FCN3 protein expression in various cell types. By understanding the role of FCN3 in immune regulation, researchers can gain insights into potential therapeutic strategies for manipulating immune responses in disease settings.
Product Name:
FCN3 Rabbit Polyclonal Antibody
SKU:
CAB17352
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 13-288 of human FCN3 (NP_775628.1).
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
Purification Method:
Affinity purification
Gene ID:
8547
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FCN3 Rabbit pAb (CAB17352) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
