The FGFR2 Polyclonal Antibody (CAB2074) is a valuable tool for researchers studying the FGFR2 protein, a receptor involved in cell growth, differentiation, and migration. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.FGFR2, a member of the fibroblast growth factor receptor family, plays a crucial role in various cellular processes, including embryonic development, tissue repair, and angiogenesis. Dysregulation of FGFR2 signaling has been implicated in various cancers and developmental disorders, making it a promising target for therapeutic interventions.
With its high reactivity and specificity, the FGFR2 Polyclonal Antibody enables precise detection and analysis of FGFR2 protein expression in different cell types, providing valuable insights for research in cancer biology, developmental biology, and regenerative medicine. By understanding the mechanisms of FGFR2 signaling, researchers can develop targeted therapies to treat FGFR2-related diseases and improve patient outcomes.
Product Name:
FGFR2 Rabbit Polyclonal Antibody
SKU:
CAB2074
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGFR2 (NP_000132.3).
Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Secreted, Single-pass type I membrane protein.
Calculated MW:
92kDa
Observed MW:
Refer to figures
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
2263
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat spleen using FGFR2 antibody (CAB2074) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
