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FITC Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL2260)

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SKU AGEL2260
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2b, κ
Clone 10F.9G2
Conjugation FITC
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Description

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FITC Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The FITC Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2) (AGEL2260) offered by AssayGenie is a cutting-edge tool designed for researchers studying immune checkpoint proteins in the context of immunotherapy and cancer research. This antibody specifically targets the PD-L1 protein, a key regulator of immune responses, particularly in the suppression of T cell activity.By utilizing this antibody, researchers can effectively detect and analyze PD-L1 expression in mouse samples, enabling detailed investigation into its role in immune evasion mechanisms within the tumor microenvironment. The high specificity and sensitivity of this antibody make it a valuable asset for understanding the interplay between PD-L1 and immune cells, providing crucial insights for the development of novel immunotherapies targeting this pathway.

PD-L1 has emerged as a critical biomarker in cancer immunotherapy, with its overexpression associated with immune evasion and resistance to treatment. By elucidating the intricate mechanisms underlying PD-L1 regulation and function, researchers can pave the way for innovative strategies to enhance the efficacy of immune checkpoint blockade therapies and combat tumor immune evasion mechanisms.In summary, the FITC Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2) (AGEL2260) from AssayGenie offers a potent and reliable tool for investigating the role of PD-L1 in immune modulation and cancer progression, making it an essential resource for researchers dedicated to advancing our understanding of immune checkpoint pathways.

Product Title:FITC Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]
SKU:AGEL2260
Size:50 Tests, 100 Tests, 200 Tests
Clone No:10F.9G2
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:FITC Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q9EP73
Gene ID:60533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

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