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FITC Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL2741)

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SKU AGEL2741
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2b, κ
Clone 10F.9G2
Conjugation FITC
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Description

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FITC Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The FITC Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2) is a versatile tool for immunology and cancer research. This antibody, available from Assay Genie, is specifically designed to target CD274 (PD-L1), a key immune checkpoint protein involved in regulating immune responses.With high reactivity towards mouse samples, this FITC-conjugated antibody is ideal for fluorescence-based applications such as flow cytometry, immunofluorescence, and fluorescence microscopy. It enables precise detection and visualization of CD274 (PD-L1) expression in various cell types, offering researchers valuable insights into the role of this protein in immune regulation and tumor immune evasion mechanisms.CD274 (PD-L1) is known for its role in suppressing T cell activity and promoting immune tolerance in the tumor microenvironment, making it a promising target for cancer immunotherapy research.

By understanding the expression and function of CD274 (PD-L1), scientists can develop innovative strategies for enhancing anti-tumor immune responses and overcoming immune checkpoint blockade resistance.Whether investigating immune checkpoint pathways, tumor immunology, or immune evasion mechanisms, the FITC Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2) from Assay Genie provides a reliable tool for precise and sensitive detection of CD274 (PD-L1) expression, facilitating groundbreaking discoveries in the field of immunotherapy and oncology.

Product Title:FITC Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]
SKU:AGEL2741
Size:25µg, 100µg
Clone No:10F.9G2
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:FITC Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q9EP73
Gene ID:60533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

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