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Key Features

FITC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23] (AGEL3378)

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SKU AGEL3378
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, k
Clone RMT3-23
Conjugation FITC
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Description

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FITC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]

The FITC Anti-Mouse CD366 (TIM-3) Antibody (RMT3-23) is a vital tool for researchers studying immune responses and cellular interactions in mouse models. This antibody, raised against the CD366 (TIM-3) protein, is conjugated with FITC for fluorescence detection and analysis. CD366 (TIM-3) is a surface molecule expressed on immune cells and is involved in immune regulation, particularly in regulating T cell function and tolerance. Its role in immune checkpoint regulation has made it a promising target for cancer immunotherapy and autoimmune disease research.

The FITC Anti-Mouse CD366 (TIM-3) Antibody (RMT3-23) enables precise detection and visualization of CD366 (TIM-3) expression in mouse tissues or cells, providing valuable insights into its function and potential therapeutic applications. This validated antibody is an essential tool for immunologists and cancer researchers exploring the complex interplay of immune checkpoints in health and disease.

Product Title:FITC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]
SKU:AGEL3378
Size:50 Tests, 100 Tests, 200 Tests
Clone No:RMT3-23
Synonyms:TIM3; TIMD3;HAVcr-2;TIMD-3;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:FITC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q8VIM0
Gene ID:84868
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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