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Key Features

FITC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23] (AGEL3379)

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SKU AGEL3379
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, k
Clone RMT3-23
Conjugation FITC
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Description

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FITC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]

The FITC Anti-Mouse CD366 (TIM-3) Antibody (RMT3-23) is a cutting-edge research tool designed for scientists investigating TIM-3, a cell surface protein with key roles in immune regulation and tolerance. This antibody, optimized for use in mouse samples, is produced using state-of-the-art techniques and has been rigorously validated for a range of applications, including flow cytometry and immunofluorescence. Its high specificity and sensitivity ensure precise detection and quantification of TIM-3 expression in various cell populations, making it an essential tool for studies in immunology and cancer immunotherapy.TIM-3, also known as T-cell immunoglobulin and mucin domain-containing protein 3, is a crucial checkpoint receptor that modulates immune responses by regulating T cell activation and tolerance.

Its involvement in immune exhaustion and regulatory pathways makes it a promising target for therapeutic interventions in cancer and chronic infections. Research on TIM-3 has revealed its complex interactions with other immune checkpoints, shedding light on potential combination therapies for enhancing anti-tumor immunity. By understanding the functions and signaling pathways of TIM-3, researchers can develop novel strategies to manipulate immune responses and improve clinical outcomes in various disease settings.

Product Title:FITC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]
SKU:AGEL3379
Size:25µg, 100µg
Clone No:RMT3-23
Synonyms:TIM3; TIMD3;HAVcr-2;TIMD-3;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:FITC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q8VIM0
Gene ID:84868
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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