The FKBP51/FKBP5 Antibody (CAB3863) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.FKBP5, a member of the FK506-binding protein (FKBP) family, is known to interact with hormone receptors and modulate their activity, ultimately influencing stress hormone signaling pathways. Dysregulation of FKBP5 has been linked to various psychiatric disorders and is a promising target for therapeutic interventions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
FKBP51/FKBP5 Antibody
SKU:
CAB3863
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
MCF7, HT-1080, SH-SY5Y, Jurkat, Mouse liver, Mouse kidney, Rat kidney
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
51kDa
Observed MW:
51kDa
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
2289
RRID
AB_2765348
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using FKBP51/FKBP5 Rabbit pAb (CAB3863) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
