The FNBP1L Polyclonal Antibody (PACO09330) is specifically designed for researchers studying FNBP1L, a protein involved in regulating cell adhesion and migration processes. This antibody, generated in rabbits, shows strong reactivity with human samples and has been validated for use in Western blot applications. By binding to the FNBP1L protein, researchers can accurately detect and analyze its expression levels in a variety of cell types, making it an essential tool for studies in cell biology and cancer research.FNBP1L, also known as formin-binding protein 1-like, plays a crucial role in the organization of the actin cytoskeleton and is involved in processes such as cell motility and adhesion.
Understanding the function of FNBP1L is essential for elucidating its role in cellular processes and its potential implications in diseases such as cancer and developmental disorders. Researchers studying cell migration, invasion, and metastasis will benefit from the use of this antibody in their experiments to further investigate the mechanisms involving FNBP1L.
formin binding protein 1-like;FNBP1L;C1orf39;TOCA1 ;
UniProt Protein Function:
FNBP1L: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. Belongs to the FNBP1 family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 1p22.1Cellular Component: cytoplasm; cytoplasmic membrane-bound vesicle; trans-Golgi networkMolecular Function: ARF guanyl-nucleotide exchange factor activity; protein bindingBiological Process: cilium biogenesis; membrane budding; membrane invagination; positive regulation of filopodium formation; vesicle organization and biogenesis; vesicle transport along actin filament
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
