The FOXN4 Polyclonal Antibody (PACO02453) is a valuable tool for research involving FOXN4, a transcription factor known for its essential role in the development of the thymus gland and T cell maturation. This antibody, produced in rabbits, is highly specific to FOXN4 and has been validated for use in various applications, including immunohistochemistry and Western blot analysis.FOXN4 is a key regulator of thymic epithelial cell differentiation and is vital for proper immune system function.
Dysregulation of FOXN4 has been linked to thymic disorders and impaired T cell development, making it a promising target for research in immunology and diseases related to immune function.Studying FOXN4 with this polyclonal antibody can provide valuable insights into thymic development, T cell maturation, and immune system disorders. Its high specificity and sensitivity make it an excellent tool for researchers interested in understanding the role of FOXN4 in health and disease.
Antibody Name:
FOXN4 Antibody
Antibody SKU:
PACO02453
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human FoxN4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
FOXN4; Forkhead box protein N4
UniProt Protein Function:
FOXN4: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell development/differentiation; DNA-binding; Transcription factorChromosomal Location of Human Ortholog: 12q24.11Cellular Component: nucleusMolecular Function: chromatin binding; transcription factor activityBiological Process: heart looping; positive regulation of transcription, DNA-dependent; regulation of heart contraction; regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]
