The GAGE12I Polyclonal Antibody (PACO19689) is a valuable tool for researchers studying GAGE12I, a cancer/testis antigen involved in tumorigenesis and metastasis. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting GAGE12I in human samples, making it ideal for applications such as Western blot analysis. By binding to the GAGE12I protein, this antibody enables accurate detection and analysis in various cancer cell types, allowing for in-depth studies in oncology and tumor immunology.
GAGE12I is a promising target for cancer research due to its restricted expression in normal tissues and aberrant expression in various cancers, including melanoma and lung cancer. Its role in promoting tumor growth and metastasis underscores its potential as a diagnostic marker and therapeutic target for cancer treatment. Investigating the function of GAGE12I is essential for developing novel approaches to cancer therapy and improving patient outcomes in oncology.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19689(GAGE12I Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: K562 cells, Primary antibody: PACO19689(GAGE12I Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19689(GAGE12I Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes.
Synonyms:
G antigen 12I
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]
