The GALR3 Polyclonal Antibody (PAC00541) is a valuable tool for researchers studying GALR3, a G protein-coupled receptor involved in various physiological processes, including the regulation of mood, stress responses, and appetite. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the GALR3 protein, facilitating its detection and analysis in different cell types, making it an excellent choice for investigations in neuroscience and endocrinology.GALR3, also known as galanin receptor 3, plays a crucial role in modulating the activity of the neuropeptide galanin, which is involved in the regulation of various physiological functions, including pain processing, memory, and energy balance.
Dysregulation of GALR3 signaling has been implicated in mood disorders, substance abuse, and metabolic disorders, making it a promising target for therapeutic interventions in these conditions. By studying the function of GALR3, researchers can gain insights into the underlying mechanisms of these disorders and develop novel treatment strategies targeting this receptor.
Antibody Name:
GALR3 Antibody (PACO05541)
Antibody SKU:
PACO05541
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human GALR3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
GALR3; GALNR3; Galanin receptor type 3; GAL3-R; GALR-3
UniProt Protein Function:
GALR3: Receptor for the hormone galanin. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCRChromosomal Location of Human Ortholog: 22q13.1Cellular Component: integral to membrane; integral to plasma membrane; plasma membraneMolecular Function: galanin receptor activity; peptide hormone bindingBiological Process: feeding behavior; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); learning and/or memory; neuropeptide signaling pathway; positive regulation of transcription from RNA polymerase II promoter; synaptic transmission
UniProt Protein Details:
NCBI Summary:
The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]
