The Gas6 Polyclonal Antibody (CAB8545) is specifically designed for research involving Gas6, a protein known for its role in cell signaling and regulation of cell growth and survival. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the Gas6 protein, this antibody allows for accurate and reliable detection and analysis in a variety of cell types, making it an essential tool for studies in cell biology and cancer research.Gas6, a member of the vitamin K-dependent protein family, functions as a ligand for the TAM receptor tyrosine kinases, playing a crucial role in regulating various cellular processes such as apoptosis, inflammation, and immunity.
Dysregulation of the Gas6/TAM signaling pathway has been linked to the development and progression of cancer, autoimmune diseases, and other pathological conditions. Therefore, understanding the activity of Gas6 is vital for uncovering its potential as a therapeutic target in these disease contexts.Overall, the Gas6 Polyclonal Antibody (CAB8545) provides researchers with a valuable tool for investigating the molecular mechanisms underlying Gas6 function and its implications in disease pathology, ultimately contributing to the development of novel therapeutic strategies for a wide range of medical conditions.
Product Name:
GAS6 Rabbit Polyclonal Antibody
SKU:
CAB8545
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human GAS6 (NP_000811.1).
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia.
Purification Method:
Affinity purification
Gene ID:
2621
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using GAS6 Rabbit pAb (CAB8545) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
