Description
GATA5 Antibody (PACO03508)
The GATA5 Polyclonal Antibody (PACO03508) is a valuable tool for researchers studying the GATA5 transcription factor involved in various biological processes, including heart development and gastrointestinal function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the GATA5 protein, researchers can accurately detect and analyze its expression in different cell types, making it a versatile tool for studies in developmental biology, cardiovascular research, and gastrointestinal disorders.
GATA5 is a key regulator of gene expression, particularly in the development and function of the heart and gastrointestinal tract. Dysregulation of GATA5 has been linked to congenital heart defects, gastrointestinal diseases, and cancer, highlighting its importance in human health. By investigating the role of GATA5 using this antibody, researchers can gain valuable insights into its function and potential therapeutic applications in various diseases.
| Antibody Name: | GATA5 Antibody |
| Antibody SKU: | PACO03508 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human GATA-5. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | GATA5; Transcription factor GATA-5; GATA-binding factor 5 |
| UniProt Protein Function: | GATA5: Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Rare variants in GATA5 may be a cause of susceptibility to atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: nucleoplasm; nucleus; transcription factor complex Molecular Function:chromatin binding; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity; zinc ion binding Biological Process: anatomical structure formation; blood coagulation; cell development; cell fate commitment; heart development; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BWX5 |
| NCBI GenInfo Identifier: | 20138325 |
| NCBI Gene ID: | 140628 |
| NCBI Accession: | Q9BWX5.1 |
| UniProt Secondary Accession: | Q9BWX5,Q17RE2, Q86VU4, D9ZGF7, |
| UniProt Related Accession: | Q9BWX5 |
| Molecular Weight: | 41,299 Da |
| NCBI Full Name: | Transcription factor GATA-5 |
| NCBI Synonym Full Names: | GATA binding protein 5 |
| NCBI Official Symbol: | GATA5Â Â |
| NCBI Official Synonym Symbols: | GATAS; bB379O24.1Â Â |
| NCBI Protein Information: | transcription factor GATA-5 |
| UniProt Protein Name: | Transcription factor GATA-5 |
| UniProt Synonym Protein Names: | GATA-binding factor 5 |
| Protein Family: | GATA transcription factor |
| UniProt Gene Name: | GATA5Â Â |
| UniProt Entry Name: | GATA5_HUMAN |
