The GCHFR Polyclonal Antibody (PAC045858) is a valuable tool for research involving the GCHFR protein, which is known to play a crucial role in the regulation of immune responses. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GCHFR protein, this antibody enables the detection and analysis of GCHFR in a variety of cell types, making it an ideal choice for studies in immunology and cancer research.GCHFR, a key player in immune regulation, is involved in modulating inflammatory responses and has been implicated in various disease processes, including cancer, autoimmune disorders, and chronic inflammatory conditions.
By gaining insight into the function of GCHFR, researchers can better understand its role in these diseases and develop targeted therapies that manipulate immune responses for therapeutic benefit. The GCHFR Polyclonal Antibody is a valuable tool for uncovering the role of GCHFR in immune regulation and disease pathogenesis, paving the way for innovative treatments and interventions.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO45858 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO45858 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Synonyms:
GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) (p35), GCHFR, GFRP
UniProt Protein Function:
GCHFR: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. Belongs to the GFRP family.Protein type: InhibitorChromosomal Location of Human Ortholog: 15q15Cellular Component: cytoplasm; cytosol; dendrite; melanosome; nuclear membrane; nucleusMolecular Function: protein bindingBiological Process: neurotransmitter metabolic process; nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity
UniProt Protein Details:
NCBI Summary:
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
