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GenieFluor 488 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL3322)

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SKU AGEL3322
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2b, k
Clone 10F.9G2
Conjugation AF488
€82 - €213

Description

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GenieFluor 488 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The GenieFluor 488 Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2) is a powerful tool for researchers studying immune checkpoint molecules. This antibody is specifically designed to target the CD274 protein, also known as PD-L1, which plays a crucial role in regulating immune responses.Through its high reactivity with mouse samples, this antibody allows for precise detection and analysis of PD-L1 in various cell types. Validated for use in a range of applications including Western blot, immunofluorescence, and flow cytometry, it provides researchers with a versatile tool for investigating the role of PD-L1 in immunology and cancer research.

PD-L1 is a key player in immune regulation, functioning as a checkpoint molecule that can inhibit T cell activation and promote immune tolerance. Understanding the expression and function of PD-L1 is essential for unraveling its impact on the immune system and its involvement in diseases such as cancer, autoimmune disorders, and infections.By using the GenieFluor 488 Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2), researchers can delve into the intricate mechanisms of immune modulation and potentially uncover new therapeutic strategies for manipulating immune responses in various disease settings.

Product Title:GenieFluor 488 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]
SKU:AGEL3322
Size:50 Tests, 100 Tests, 200 Tests
Clone No:10F.9G2
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 488 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q9EP73
Gene ID:60533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

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