The GENIEfluor 647 Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2) is a cutting-edge tool for scientists conducting research on immune checkpoints and cancer immunotherapy. This antibody is specifically designed to target mouse programmed cell death ligand 1 (PD-L1), a key immune checkpoint protein that plays a critical role in regulating the immune response.PD-L1 is known for its involvement in suppressing the immune system's ability to attack cancer cells, making it a promising target for cancer immunotherapy. The GENIEfluor 647 Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2) is highly specific and sensitive, enabling accurate detection and analysis of PD-L1 expression in mouse samples.Utilizing state-of-the-art technology, this antibody is validated for use in various applications, including immunofluorescence, flow cytometry, and immunohistochemistry.
Its versatility allows researchers to explore PD-L1 expression in different cell types and tissue samples, providing valuable insights into the role of PD-L1 in cancer progression and immune evasion.By using the GENIEfluor 647 Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2) in their studies, researchers can advance our understanding of immune checkpoint pathways and develop novel strategies to harness the immune system's potential in the fight against cancer. This antibody is a powerful tool for immunology and cancer research, offering precise and reliable results that can drive groundbreaking discoveries in the field.
Genie Fluor 647 Rat IgG2b, κ Isotype Control[LTF-2]
Form:
Liquid
Conjugation:
Genie Fluor647
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
Q9EP73
Gene ID:
60533
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
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