The GenieFluor 647 Anti-Mouse H-2 Antibody (M1/42) (AGEL2417) is a powerful tool designed for immunological research involving mouse models. This monoclonal antibody, specifically targeting the H-2 antigen, is ideal for applications such as flow cytometry, immunofluorescence, and immunohistochemistry. Its high specificity and sensitivity make it a reliable choice for detecting and analyzing H-2 expression in various tissues and cell types.The H-2 antigen, a major histocompatibility complex (MHC) molecule, plays a crucial role in antigen presentation and immune responses in mice.
Understanding its expression pattern and regulation is essential for investigating immune mechanisms, transplant biology, and autoimmune diseases in preclinical studies. The GenieFluor 647 Anti-Mouse H-2 Antibody (M1/42) provides researchers with a valuable tool to explore the function and dynamics of H-2 antigens in different biological contexts, aiding in the development of novel therapeutic strategies and immunotherapies.
Product Title:
GenieFluor 647 Anti-Mouse H-2 Antibody [M1/42]
SKU:
AGEL2417
Size:
50 Tests, 100 Tests, 200 Tests
Clone No:
M1/42
Synonyms:
Mouse major histocompatibility complex (MHC) H-2; MHC I;
Host Species:
Rat
Reactivity:
Mouse
Application:
FCM
Isotype:
Rat IgG2a, κ
Isotype Control:
Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:
Liquid
Conjugation:
Genie Fluor647
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Gene ID:
111364
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
The M1/42 antibody reacts with the H-2 MHC class I alloantigens expressed on nucleated cells from mice of the a, b, d, j, k, s, and u haplotypes (Stallcup, KC et al, 1981). MHC class I is involved in antigen presentation to T cells expressing CD3/TCR and CD8 proteins.
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