The GFRA4 Polyclonal Antibody (PAC018433) is a crucial tool for researchers studying the GFRA4 protein, a key player in the development and maintenance of the nervous system. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for a variety of research applications, including Western blotting.GFRA4, also known as Glial Cell Line-Derived Neurotrophic Factor Family Receptor Alpha 4, is involved in the regulation of neuronal survival and growth through its interactions with GDNF family ligands. Dysregulation of GFRA4 has been implicated in various neurological disorders, making it a promising target for therapeutic interventions.
Researchers in the fields of neuroscience, neurobiology, and developmental biology will find the GFRA4 Polyclonal Antibody invaluable for studying the function and expression of GFRA4 in different cell types and tissues. By gaining a better understanding of GFRA4's role in neuronal development and maintenance, scientists can potentially uncover new insights into neurodegenerative diseases and pave the way for novel treatment strategies.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18433(GFRA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: 293T cells, Primary antibody: PACO18433(GFRA4 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18433(GFRA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms:
GDNF family receptor α 4
UniProt Protein Function:
GFRA4: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Belongs to the GDNFR family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, GPI anchorChromosomal Location of Human Ortholog: 20p13-p12Cellular Component: plasma membraneMolecular Function: Ras guanyl-nucleotide exchange factor activityBiological Process: MAPKKK cascade
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
