The GGT5 Polyclonal Antibody (CAB14374) is a powerful tool for researchers studying the GGT5 enzyme, a key player in the metabolism of glutathione and other biochemical processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the GGT5 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component in studies related to biochemistry, toxicology, and cancer research.
GGT5, also known as gamma-glutamyltransferase 5, is involved in the breakdown and recycling of glutathione, an important antioxidant in the body. Dysregulation of GGT5 has been linked to oxidative stress, liver diseases, and cancer development, making it a promising target for therapeutic interventions. Investigating the role of GGT5 and its potential inhibitors may lead to new treatments for conditions associated with oxidative damage and impaired detoxification pathways.
Product Name:
GGT5 Rabbit Polyclonal Antibody
SKU:
CAB14374
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 388-587 of human GGT5 (NP_001093251.1).
This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
2687
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HT-29 cells, using GGT5 Rabbit pAb (CAB14374) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
