The GINS1 Antibody (PAC019240) is a high-quality polyclonal antibody designed for research involving the GINS1 protein. GINS1 is a key component of the GINS complex, which plays a critical role in DNA replication and cell proliferation. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.By binding specifically to the GINS1 protein, this antibody enables accurate detection and analysis in different cell types, making it an essential tool for studying DNA replication and cell cycle regulation.
Its versatility and reliability make it ideal for research in molecular biology, cancer biology, and developmental biology.Understanding the function and regulation of GINS1 is crucial for unraveling the mechanisms underlying DNA replication and cell division, with implications for diseases such as cancer and developmental disorders. By using the GINS1 Antibody, researchers can advance their studies and contribute to the broader understanding of cellular processes and disease pathways.
Antibody Name:
GINS1 Antibody (PACO19240)
Antibody SKU:
PACO19240
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human GINS1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19240(GINS1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19240(GINS1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
DNA replication complex GINS protein PSF1 is a protein that in humans is encoded by the GINS1 gene. The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function. Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro.
Synonyms:
GINS complex subunit 1 (Psf1 homolog)
UniProt Protein Function:
GINS1: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function. Belongs to the GINS1/PSF1 family.Protein type: Motility/polarity/chemotaxis; DNA replicationChromosomal Location of Human Ortholog: 20p11.21Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: 3'-5' DNA helicase activityBiological Process: DNA strand elongation during DNA replication
UniProt Protein Details:
NCBI Summary:
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008]
