The GJA3 Polyclonal Antibody (PACO03869) is a valuable tool for researchers studying GJA3, a gap junction protein involved in cell communication and tissue homeostasis. This antibody, generated in rabbits, has high specificity for GJA3 in human samples and is validated for use in Western blot applications. By binding to the GJA3 protein, this antibody allows for precise detection and analysis in various cell types, making it suitable for research in cell biology and developmental biology.
GJA3, also known as connexin 46, plays a crucial role in gap junction-mediated intercellular communication, which is essential for maintaining the function and integrity of tissues. Dysfunction of GJA3 has been associated with various diseases, including cataracts and cardiovascular disorders. Investigating the functions of GJA3 using this antibody can provide valuable insights into the mechanisms of these diseases and potentially lead to the development of targeted therapies.
Antibody Name:
GJA3 Antibody
Antibody SKU:
PACO03869
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Connexin 46.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
GJA3; Gap junction alpha-3 protein; Connexin-46; Cx46
UniProt Protein Function:
GJA3: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA3 are the cause of cataract zonular pulverulent cataract type 3 (CZP3). A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. Defects in GJA3 are a cause of cataract autosomal dominant (ADC). Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Belongs to the connexin family. Alpha-type (group II) subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 13q12.11Biological Process: cell-cell signaling; visual perceptionDisease: Cataract 14, Multiple Types
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010]
