The GJB5 Polyclonal Antibody (PAC021018) is a valuable tool for researchers studying the function of GJB5, a protein involved in cell communication and skin barrier function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the GJB5 protein, researchers can detect and analyze its expression in various cell types, making it a versatile option for investigating skin biology and related diseases.
GJB5, also known as connexin 31.1, is a key player in maintaining the integrity of the skin barrier and facilitating communication between cells. Its role in regulating skin hydration and barrier function makes it a promising target for research on skin disorders such as ichthyosis and other genetic conditions affecting skin health. By studying the function of GJB5, researchers can gain insights into potential therapeutic strategies for managing skin diseases and improving skin barrier function.
Antibody Name:
GJB5 Antibody (PACO21018)
Antibody SKU:
PACO21018
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human GJB5
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 µg, Lane: Human placenta tissue, Primary antibody: PACO21018(GJB5 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds.
Background:
This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer.
Synonyms:
gap junction protein, β 5, 31.1kDa
UniProt Protein Function:
GJB5: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily.Protein type: Cell adhesion; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 1p35.1Biological Process: epidermis development
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012]
