The GJB7 Antibody (PAC022344) is a highly specific and sensitive tool for researchers studying the role of GJB7 in various physiological and pathological processes. GJB7, also known as Connexin25, is a gap junction protein involved in cell communication and homeostasis. This polyclonal antibody, produced in rabbits, is optimized for use in Western blot assays and has been validated for detection of GJB7 in human samples. Its high reactivity and specificity make it ideal for studies in cell biology, neurobiology, and developmental biology.
By targeting GJB7, researchers can explore its role in cell signaling, tissue development, and disease progression. This antibody provides a valuable tool for investigating the mechanisms underlying gap junction function and dysfunction, with potential implications for understanding and treating various disorders.
Antibody Name:
GJB7 Antibody (PACO22344)
Antibody SKU:
PACO22344
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human GJB7.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HT-29 cells, using GJB7 antibody.
Background:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell By similarity.
Synonyms:
connexin25; CX25; CXB7; gap junction protein; beta 7
UniProt Protein Function:
GJB7: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 6q15Cellular Component: connexon complex; integral to membraneBiological Process: cell communication
UniProt Protein Details:
NCBI Summary:
Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
