The GJB7 Antibody (PAC037014) is a valuable tool for researchers studying the role of GJB7, a member of the gap junction beta family involved in cell communication and signaling. This polyclonal antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in various research applications.GJB7 plays a crucial role in cell-to-cell communication, facilitating the exchange of ions and small molecules between cells. Dysregulation of GJB7 has been linked to various diseases, including skin disorders and certain cancers.
By targeting GJB7 with this antibody, researchers can study its expression levels and localization in different cell types, providing insights into its function and potential implications for disease progression.With its validated performance in Western blot applications, the GJB7 Antibody offers researchers a reliable tool for investigating the role of GJB7 in both normal physiological processes and disease states. Its versatility and specificity make it a valuable asset for studies in cell biology, oncology, and molecular biology.
Antibody Name:
GJB7 Antibody (PACO37014)
Antibody SKU:
PACO37014
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Gap junction beta-7 protein (41-75AA)
Immunofluorescent analysis of A431 cells using PACO37014 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Synonyms:
Gap junction beta-7 protein (Connexin-25) (Cx25), GJB7, CX25
UniProt Protein Function:
GJB7: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 6q15Cellular Component: connexon complex; integral to membraneBiological Process: cell communication
UniProt Protein Details:
NCBI Summary:
Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
