The GNG5 Antibody (PAC027089) is a polyclonal antibody designed for research involving G protein subunit gamma 5 (GNG5), a signaling protein involved in various cellular processes. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot and immunohistochemistry applications.GNG5 is a crucial component of the G protein complex, which plays a crucial role in signal transduction pathways in cells. By targeting GNG5 with this antibody, researchers can study its function and involvement in diseases such as cancer, neurological disorders, and cardiovascular diseases.
With its high specificity and reactivity, the GNG5 Antibody is a valuable tool for scientists studying G protein signaling pathways and their impact on cellular function. Its ability to detect and analyze GNG5 protein levels in various cell types makes it a essential for research in molecular biology, pharmacology, and drug development.
Immunohistochemistry of paraffin-embedded human liver cancer using PACO27089 at dilution of 1:100.
Immunofluorescent analysis of PC-3 cells using PACO27089 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO27089 at dilution of 1:100.
Background:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The β and γ chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Synonyms:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5, GNG5, GNGT5
UniProt Protein Function:
G-gamma 5: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the G protein gamma family.Protein type: G protein, heterotrimeric; G protein, heterotrimeric gamma; G protein; MitochondrialChromosomal Location of Human Ortholog: 1p22Cellular Component: membrane; plasma membraneMolecular Function: PDZ domain binding; protein binding
UniProt Protein Details:
NCBI Summary:
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
