The GNG5 Polyclonal Antibody (PACO22363) is a vital tool for researchers studying the GNG5 protein, a key player in signal transduction pathways and cellular signaling processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting GNG5 in human samples, making it an excellent choice for Western blot applications.GNG5, a member of the G protein family, plays a crucial role in mediating intracellular signaling cascades and regulating various cellular functions. Dysregulation of GNG5 has been implicated in a variety of diseases, including cancer, neurological disorders, and cardiovascular conditions, making it an attractive target for therapeutic interventions.
By utilizing the GNG5 Polyclonal Antibody, researchers can effectively study the expression and function of GNG5 in different cell types and physiological conditions, enhancing our understanding of its role in disease pathogenesis. This antibody is a valuable resource for investigations in molecular biology, pharmacology, and drug development, offering valuable insights into the potential therapeutic targeting of GNG5 in various disease states.
Antibody Name:
GNG5 Antibody (PACO22363)
Antibody SKU:
PACO22363
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:100-1:500
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human GNG5.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunofluorescence analysis of A549 cells, using GNG5 antibody.
Background:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Synonyms:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5;
UniProt Protein Function:
G-gamma 5: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the G protein gamma family.Protein type: G protein, heterotrimeric; G protein, heterotrimeric gamma; G protein; MitochondrialChromosomal Location of Human Ortholog: 1p22Cellular Component: membrane; plasma membraneMolecular Function: PDZ domain binding; protein binding
UniProt Protein Details:
NCBI Summary:
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
