The GP6 Polyclonal Antibody (CAB14999) is a vital tool for researchers studying the role of GP6, a platelet glycoprotein involved in platelet activation and aggregation. This antibody, produced using rabbit immunogens, has a high specificity for GP6 in human samples and is validated for use in Western blotting applications. By binding to the GP6 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in hemostasis, thrombosis, and cardiovascular diseases.
GP6 is a key player in platelet function, playing a crucial role in maintaining vascular integrity and regulating blood clot formation. Dysregulation of GP6 has been linked to various thrombotic disorders, making it a promising target for therapeutic interventions aimed at preventing or treating conditions such as heart attacks and strokes. By understanding the functional role of GP6, researchers can develop new strategies to modulate platelet activity and improve patient outcomes in cardiovascular health.
Product Name:
GP6 Rabbit Polyclonal Antibody
SKU:
CAB14999
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 21-267 of human GP6 (NP_057447.5).
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
51206
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using GP6 Rabbit pAb (CAB14999) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
