The GPR1 Polyclonal Antibody (PAC056808) is a crucial tool for researchers studying GPR1, a G protein-coupled receptor involved in various physiological processes, including immune regulation and inflammation. This antibody, produced in rabbits, is specifically designed for detecting GPR1 in human samples and has been validated for use in Western blot applications.GPR1, also known as the G protein-coupled receptor 1, plays a key role in modulating immune responses and inflammatory pathways. Its involvement in these processes makes it a promising target for research in fields such as immunology and cancer biology.
By using this antibody, researchers can detect and analyze GPR1 expression in different cell types, providing valuable insights into its function and potential implications in disease.Understanding the role of GPR1 in immune regulation and inflammation is essential for developing targeted therapies for conditions such as cancer, autoimmune disorders, and chronic inflammatory diseases. The GPR1 Polyclonal Antibody offers a reliable and efficient way to study this important receptor and advance our knowledge in these critical areas of research.
IHC image of PACO56808 diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with PACO56808 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.
Synonyms:
G-protein coupled receptor 1, GPR1
UniProt Protein Function:
GPR1: Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1. Belongs to the G-protein coupled receptor 1 family.Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 2q33.3Cellular Component: neuron projection; integral to plasma membraneMolecular Function: G-protein coupled receptor activity; neuropeptide bindingBiological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway
