The GPR132 Polyclonal Antibody (PACO09558) is an essential tool for researchers studying G protein-coupled receptor 132 (GPR132), a key protein involved in immune regulation and inflammation. This antibody, derived from rabbit serum, is highly specific to human samples and has been validated for use in Western blotting applications. Its ability to specifically bind to the GPR132 protein allows for accurate detection and analysis in a variety of cell types, making it an invaluable asset for studies in immunology and inflammatory disease research.GPR132, also known as G2A receptor, plays a crucial role in modulating immune responses and inflammation by regulating various signaling pathways. Its dysregulation has been implicated in various pathological conditions, including autoimmune diseases, inflammatory disorders, and cancer.
Therefore, understanding the function and expression of GPR132 is essential for developing potential therapeutic strategies targeting this receptor to treat immune-mediated diseases and inflammatory conditions.Overall, the GPR132 Polyclonal Antibody (PACO09558) is a high-quality reagent that can significantly advance research in immunology, inflammation, and related fields by enabling precise detection and characterization of GPR132 in biological samples. Its reliability and specificity make it an indispensable tool for scientists investigating the role of GPR132 in health and disease.
G protein-coupled receptor 132;GPR132;G2A;MGC99642 ;
UniProt Protein Function:
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
