Description
GPR75 Antibody (PACO27169)
The GPR75 Polyclonal Antibody (PAC027169) is a valuable tool for researchers studying GPR75, a G protein-coupled receptor known for its role in various physiological processes, including metabolism and appetite regulation. This antibody, produced in rabbits, exhibits high specificity for human samples and is optimized for use in Western blotting applications.GPR75 is a receptor that has been implicated in energy balance and obesity, making it a target of interest in research related to metabolic disorders and potential therapeutic interventions. By targeting GPR75, researchers can gain insights into its signaling pathways and how they may be manipulated to regulate weight and metabolism.
The GPR75 Polyclonal Antibody is an essential component for investigating the function and expression of GPR75 in different cell types and tissues. Its reliability and specificity make it an invaluable tool for studies in the fields of metabolism, obesity, and drug development. By utilizing this antibody, researchers can further advance our understanding of GPR75 and its implications in various disease states.
| Antibody Name: | GPR75 Antibody (PACO27169) |
| Antibody SKU: | PACO27169 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Probable G-protein coupled receptor 75 protein (372-540AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: GPR75 antibody at 8µg/ml + HT29 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 59 kDa Observed band size: 59 kDa . |
 | Immunofluorescent analysis of HepG2 cells using PACO27169 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO27169 at dilution of 1:100. |
| Background: | G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. |
| Synonyms: | Probable G-protein coupled receptor 75, GPR75 |
| UniProt Protein Function: | GPR75: Orphan receptor. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integralChromosomal Location of Human Ortholog: 2p16Cellular Component: integral to plasma membraneMolecular Function: C-C chemokine receptor activity; G-protein coupled receptor activityBiological Process: cell surface receptor linked signal transduction; G-protein coupled receptor protein signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002] |
| UniProt Code: | O95800 |
| NCBI GenInfo Identifier: | 67460986 |
| NCBI Gene ID: | 10936 |
| NCBI Accession: | O95800.1 |
| UniProt Secondary Accession: | O95800,Q6NWR2, B2RC02 |
| UniProt Related Accession: | O95800 |
| Molecular Weight: | 59,359 Da |
| NCBI Full Name: | Probable G-protein coupled receptor 75 |
| NCBI Synonym Full Names: | G protein-coupled receptor 75 |
| NCBI Official Symbol: | GPR75Â Â |
| NCBI Official Synonym Symbols: | GPRchr2; WI31133Â Â |
| NCBI Protein Information: | probable G-protein coupled receptor 75 |
| UniProt Protein Name: | Probable G-protein coupled receptor 75 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Probable G-protein coupled receptor |
| UniProt Gene Name: | GPR75Â Â |
| UniProt Entry Name: | GPR75_HUMAN |
| Antibodies |
| GPR75 Antibody (PACO02381) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
