The GPVI/GP6 Polyclonal Antibody (CAB24524) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced through immunization of rabbits, demonstrates high specificity and sensitivity when used in Western blotting and immunohistochemistry applications with human samples.GPVI and GP6 are crucial for mediating platelet adhesion and aggregation in response to vascular injury, playing a pivotal role in hemostasis and thrombosis. Dysregulation of these receptors has been linked to various cardiovascular diseases, making them important targets for therapeutic development and understanding disease mechanisms.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
GPVI/GP6 Polyclonal Antibody
SKU:
CAB24524
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
Gpvi, Gm469, 9830166G18Rik, GPVI/GP6
Positive Sample:
Human plasma
Calculated MW:
34kDa
Observed MW:
60kDa
Enables collagen binding activity and collagen receptor activity. Involved in vasculature development. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Is integral component of plasma membrane. Is expressed in bone marrow; femur; liver; and spleen. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 11. Orthologous to human GP6 (glycoprotein VI platelet).
Purification Method
Affinity purification
Gene ID
243816
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from Human plasma, using GPVI/GP6 Rabbit pAb (CAB24524) at 1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
