The GREB1 Polyclonal Antibody (PACO19742) is a valuable tool for researchers studying GREB1, a protein involved in hormone-dependent gene regulation and breast cancer progression. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the GREB1 protein, this antibody enables the detection and analysis of GREB1 expression in various cell types, making it ideal for investigations in endocrinology and cancer research.GREB1 (growth regulation by estrogen in breast cancer) is known to play a crucial role in estrogen receptor-positive breast cancer, where it promotes cell proliferation and tumorigenesis.
Its involvement in hormone signaling pathways makes it a promising target for therapeutic interventions aimed at treating hormone-dependent cancers. Studying the function of GREB1 is essential for advancing our understanding of breast cancer biology and improving treatment strategies for patients with this subtype of the disease.
Antibody Name:
GREB1 Antibody (PACO19742)
Antibody SKU:
PACO19742
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human GREB1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19742(GREB1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19742(GREB1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
