The GRIN1 Polyclonal Antibody (CAB7167) is a valuable tool for researchers studying the GRIN1 protein, a key component of the NMDA receptor complex involved in synaptic plasticity and memory formation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GRIN1 protein, this antibody allows for the detection and analysis of GRIN1 in various cell types, making it ideal for studies in neuroscience, neurology, and psychiatric disorders.GRIN1, also known as the NMDA receptor subunit 1, is critical for the proper functioning of excitatory neurotransmission in the brain.
Dysregulation of the NMDA receptor complex, including GRIN1, has been implicated in various neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and epilepsy. Understanding the role of GRIN1 is essential for developing targeted therapies that modulate NMDA receptor function and treat these disorders effectively.Overall, the GRIN1 Polyclonal Antibody (CAB7167) provides researchers with a reliable tool for studying the GRIN1 protein and its role in brain function and neurological disorders. Its high specificity and sensitivity make it a valuable asset in advancing our understanding of the NMDA receptor complex and its implications for human health.
Product Name:
NMDAR1 Rabbit Polyclonal Antibody
SKU:
CAB7167
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human NMDAR1 (NP_015566.1).
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
2902
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NMDAR1 antibody (CAB7167).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
