The GRM5 Polyclonal Antibody (CAB9819) is a versatile tool for researchers studying the metabotropic glutamate receptor 5 (GRM5) protein. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding specifically to the GRM5 protein, this antibody allows for the detection and analysis of GRM5 in various cell types.GRM5 is a key player in the regulation of glutamatergic signaling in the brain, making it a crucial target for research on neurological disorders such as Alzheimer's disease, schizophrenia, and epilepsy.
Understanding the function and expression of GRM5 can provide valuable insights into the molecular mechanisms underlying these conditions and may lead to the development of novel therapeutic strategies.Overall, the GRM5 Polyclonal Antibody is a valuable tool for researchers working in the fields of neuroscience and neurology, providing a reliable means to study the role of GRM5 in health and disease.
Product Name:
GRM5 Rabbit Polyclonal Antibody
SKU:
CAB9819
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 870-1070 of human GRM5 (NP_001137303.1).
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2915
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GRM5 antibody (CAB9819) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
