Description
GSTA4 Monoclonal Antibody (CAB23555)
The GSTA4 Monoclonal Antibody (CAB23555) is a high-quality antibody developed for reliable detection and analysis of target proteins. This monoclonal antibody, generated in mouse, exhibits high specificity and sensitivity towards human samples, making it ideal for various research applications, including Western blot and immunohistochemistry.GSTA4 plays a critical role in cellular defense against oxidative stress and toxic compounds by facilitating the conjugation of glutathione to xenobiotics. Dysregulation of GSTA4 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it an attractive target for therapeutic intervention.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
| Product Name: | GSTA4 Monoclonal Antibody |
| SKU: | CAB23555 |
| Size: | 20μL, 100μL |
| Reactivity: | Human |
| Clone Number: | ARC3110 |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||
| Sequence: | Email for sequence | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | GTA4, GSTA4-4, GSTA4 |
| Positive Sample: | 293T, Hep G2 |
| Cellular Localization: | Cytoplasm. |
| Calculated MW: | 26kDa |
| Observed MW: | 26kDa |
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis.
| Purification Method | Affinity purification |
| Gene ID | 2941 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of lysates from 293T cells, using GSTA4 Rabbit mAb (CAB23555) at 1:800 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s. |
 | Western blot analysis of lysates from HepG2 cells, using GSTA4 Rabbit mAb (CAB23555) at 1:800 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s. |
