The GSTM2 Antibody (CAB13496) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding to the GSTM2 protein, this antibody enables researchers to detect and analyze GSTM2 expression in various cell types, making it ideal for studies in toxicology, drug metabolism, and cancer research.GSTM2 plays a crucial role in the detoxification of electrophilic compounds by conjugating them with glutathione, protecting cells from damage caused by oxidative stress and environmental toxins.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
GSTM2 Antibody
SKU:
CAB13496
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
GST4, GSTM, GTHMUS, GSTM2-2, GSTM2
Positive Sample:
Mouse testis
Cellular Localization:
Cytoplasm.
Calculated MW:
26kDa
Observed MW:
27kDa
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
Purification Method
Affinity purification
Gene ID
2946
RRID
AB_2760359
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from mouse testis, using GSTM2 Rabbit pAb (CAB13496) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
