The GUF1 Polyclonal Antibody (PACO09648) is a valuable tool for researchers studying GUF1, a protein involved in RNA metabolism and mitochondrial function. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GUF1 protein, researchers can accurately detect and analyze its expression in a variety of cell types.GUF1 is known to be essential for mitochondrial translation and maintenance, making it a significant target for studies in cell biology and mitochondrial dysfunction.
Dysregulation of GUF1 has been linked to various diseases, including neurodegenerative disorders and metabolic syndromes. By investigating the role of GUF1 in these conditions, researchers can gain insights into potential therapeutic targets and pathways for treatment development.
GUF1 GTPase homolog (S. cerevisiae);GUF1;FLJ13220 ;
UniProt Protein Function:
GUF1: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Belongs to the GTP-binding elongation factor family. LepA subfamily.Protein type: Mitochondrial; EC 3.6.5.-Chromosomal Location of Human Ortholog: 4p12Cellular Component: mitochondrial matrix; mitochondrial inner membraneMolecular Function: GTPase activity; GTP binding; ribosome bindingBiological Process: positive regulation of translation; translation
