Description
H2AFY2 Antibody (PACO09659)
The H2AFY2 Polyclonal Antibody (PACO09659) is a valuable tool for researchers studying the histone variant H2AFY2, a key player in chromatin structure and gene regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting H2AFY2 in various research applications, including immunofluorescence and immunohistochemistry.H2AFY2 is known to be involved in gene expression regulation, DNA repair, and chromatin remodeling processes, making it a crucial target for investigations into epigenetics and cellular processes.
Understanding the function of H2AFY2 can provide insights into its roles in development, disease progression, and other biological processes, potentially leading to novel therapeutic strategies in areas such as cancer and developmental disorders.Overall, the H2AFY2 Polyclonal Antibody (PACO09659) offers researchers a reliable tool for studying the functions and dynamics of H2AFY2 in various biological contexts, paving the way for advancements in the understanding of chromatin biology and gene regulation.
| Antibody Name: | H2AFY2 Antibody (PACO09659) |
| Antibody SKU: | PACO09659 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human H2AFY2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | H2A histone family, member Y2;H2AFY2;macroH2A2 ; |
| UniProt Protein Function: | H2AFY2: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: Barr body; ESC/E(Z) complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm Molecular Function:chromatin DNA binding Biological Process: brain development; chromatin silencing; dosage compensation; negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; positive regulation of keratinocyte differentiation; regulation of cell growth |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015] |
| UniProt Code: | Q9P0M6 |
| NCBI GenInfo Identifier: | 12585260 |
| NCBI Gene ID: | 55506 |
| NCBI Accession: | Q9P0M6.3 |
| UniProt Secondary Accession: | Q9P0M6,Q5SQT2, |
| UniProt Related Accession: | Q9P0M6 |
| Molecular Weight: | 40,058 Da |
| NCBI Full Name: | Core histone macro-H2A.2 |
| NCBI Synonym Full Names: | H2A histone family member Y2 |
| NCBI Official Symbol: | H2AFY2Â Â |
| NCBI Official Synonym Symbols: | macroH2A2Â Â |
| NCBI Protein Information: | core histone macro-H2A.2 |
| UniProt Protein Name: | Core histone macro-H2A.2 |
| Protein Family: | Core histone macro |
| UniProt Gene Name: | H2AFY2Â Â |
| UniProt Entry Name: | H2AW_HUMAN |
