The HDC Polyclonal Antibody (CAB5465) is a valuable tool for researchers studying HDC (Histidine Decarboxylase), an enzyme involved in the biosynthesis of histamine. Histamine is a biogenic amine with various physiological functions, including immune response regulation and neurotransmission. The antibody is raised in rabbits and is highly specific to human samples, making it suitable for a range of applications such as Western blot and immunohistochemistry.Histidine Decarboxylase (HDC) is a key enzyme in the histamine synthesis pathway and plays a crucial role in allergic reactions, inflammation, and other immune responses.
Research on HDC can provide insights into the mechanisms underlying these processes and help in the development of novel therapies for allergy-related disorders and inflammatory conditions. By detecting and analyzing HDC expression levels in different cell types, the HDC Polyclonal Antibody facilitates research in immunology, allergy, and inflammation, offering researchers a deeper understanding of histamine regulation and its implications for human health.
Product Name:
HDC Rabbit Polyclonal Antibody
SKU:
CAB5465
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 453-662 of human HDC (NP_002103.2).
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.
Purification Method:
Affinity purification
Gene ID:
3067
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HDC antibody (CAB5465) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
