The HID1 Polyclonal Antibody (PAC019502) is a valuable tool for researchers studying the HID1 protein, a crucial component involved in cellular function and metabolism. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the HID1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and metabolic research.
HID1 is known for its role in regulating mitochondrial function and energy metabolism, making it a key player in maintaining cellular homeostasis. Dysregulation of HID1 has been linked to metabolic disorders, neurodegenerative diseases, and cancer, highlighting its importance in disease pathology. By understanding the function of HID1, researchers can potentially develop targeted therapies for a range of metabolic and neurodegenerative conditions.
Antibody Name:
HID1 Antibody (PACO19502)
Antibody SKU:
PACO19502
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human HID1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19502(HID1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
C17orf28 (chromosome 17 open reading frame 28) is a 788 amino acid, multi-pass membrane protein that is expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. C17orf28 may be involved in the development of cancers in a broad range of tissues. Existing as three alternatively spliced isoforms, C17orf28 is encoded by a gene mapping to human chromosome 17, which makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.
Synonyms:
HID1 domain containing
UniProt Protein Function:
HID1: May play an important role in the development of cancers in a broad range of tissues. Belongs to the hid-1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; DNA-bindingChromosomal Location of Human Ortholog: 17q25.1Cellular Component: cytoplasm; cytoplasmic microtubule; Golgi apparatus; Golgi medial cisterna; Golgi trans cisternaMolecular Function: protein bindingBiological Process: intracellular protein transport; response to brefeldin A
