The HIPK1 Monoclonal Antibody (PAC019758) is an essential tool for researchers studying the HIPK1 protein, a key regulator of cellular processes such as apoptosis, DNA damage response, and gene transcription. This antibody is specifically designed for use in Western blot, immunoprecipitation, and immunofluorescence applications.HIPK1, or homeodomain-interacting protein kinase 1, is known for its role in various cellular pathways, including cell growth, differentiation, and survival. Dysregulation of HIPK1 has been linked to conditions such as cancer, neurodegenerative diseases, and developmental disorders, making it a promising target for therapeutic interventions.
The PAC019758 antibody, developed using advanced monoclonal antibody technology, offers high specificity and sensitivity for detecting HIPK1 in human samples. Its ability to accurately identify and quantify HIPK1 levels in cell lysates and tissue samples makes it an invaluable tool for research in molecular biology, oncology, and neurology. Get reliable and reproducible results with the HIPK1 Monoclonal Antibody from AssayGenie.
Antibody Name:
HIPK1 Antibody (PACO19758)
Antibody SKU:
PACO19758
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human HIPK1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19758(HIPK1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19758(HIPK1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
Synonyms:
homeodomain interacting protein kinase 1
UniProt Protein Function:
HIPK1: homeodomain interacting protein kinase 1 is a CMGC kinase of the DYRK family. May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Expression elevated in many breast cancer cell lines. Null mice are resistant to carcinogens. Binds the p53 tumor suppressor. 4 alternatively spliced isoforms of the human protein have been described.Protein type: Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CMGC group; DYRK family; HIPK subfamilyChromosomal Location of Human Ortholog: 1p13.2Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: protein bindingBiological Process: eye development; positive regulation of angiogenesis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
