The HIPK4 Polyclonal Antibody (PAC023758) offered by AssayGenie is a valuable tool for researchers studying the HIPK4 protein, a key regulator of various cellular processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to HIPK4, this antibody allows for the detection and analysis of HIPK4 expression in different cell types, making it an ideal choice for studies in cell signaling, gene regulation, and cancer biology.
HIPK4 is a protein kinase that functions in diverse cellular pathways, including cell proliferation, apoptosis, and DNA damage response. Its involvement in these processes highlights its importance in normal cell function and its potential role in disease development. Research into the function and regulation of HIPK4 is essential for a better understanding of its impact on cellular physiology and its potential as a target for therapeutic interventions in diseases such as cancer and neurodegenerative disorders.
Synthesized peptide derived from internal of human HIPK4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HUVEC cells, using HIPK4 antibody.
Immunofluorescence analysis of A549 cells, using HIPK4 antibody.
Immunohistochemistry analysis of paraffin-embedded human testis tissue using HIPK4 antibody.
Background:
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter By similarity. May act as a corepressor of transcription factors Potential.
Synonyms:
Homeodomain-interacting protein kinase 4; EC 2.7.11.1; HIPK4;
UniProt Protein Function:
HIPK4: a CMGC kinase of the DYRK family.Protein type: EC 2.7.11.1; Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; DYRK family; HIPK subfamilyChromosomal Location of Human Ortholog: 19q13.2Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]
