The Hist1H2AH Antibody (PAC01642) is a polyclonal antibody designed for research involving the Hist1H2AH protein, a member of the histone H2A family. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in various research applications.Hist1H2AH is a key player in chromatin structure and gene regulation, making it a valuable target for studies in epigenetics and gene expression. By binding to the Hist1H2AH protein, this antibody enables researchers to detect and analyze chromatin modifications in different cell types, providing insights into gene regulation processes.
The significance of Hist1H2AH in chromatin remodeling suggests its role in various biological processes, including development, disease progression, and response to environmental factors. Research using this antibody may lead to a better understanding of epigenetic regulation and its impact on human health, offering potential insights into diseases such as cancer, neurological disorders, and aging-related conditions.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16462(HIST1H2AH Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Mouse liver tissue, HepG2 cells, 293T cells, Hela cells, Raji cells, A375 cells, K562 cells, Primary antibody: PACO16462(HIST1H2AH Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16462(HIST1H2AH Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.
Synonyms:
histone cluster 1, H2ah
UniProt Protein Function:
HIST1H2AH: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2A family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p21.33Cellular Component: nucleosome; nucleusMolecular Function: DNA binding; protein heterodimerization activity
UniProt Protein Details:
NCBI Summary:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008]
